Trazodone Hydrochloride and Ziprasidone Hydrochloride: Interaction Overview

Trazodone Hydrochloride (Desyrel) + Ziprasidone Hydrochloride (Geodon)

Severity: Minor

FDA label text mentions this combination without strong caution language. It is still worth confirming with your prescriber or pharmacist.

Basis: Drug interactions section of the Trazodone Hydrochloride FDA label.

What the FDA Label Says

Examples Class 1A antiarrhythmics: quinidine, procainamide, disopyramide; Class 3 antiarrhythmics: amiodarone, sotalol; Antipsychotics: ziprasidone, chlorpromazine, thioridazine; Antibiotics: gatifloxacin

Excerpt from the FDA prescribing label for Trazodone Hydrochloride (SPL set ID 007f38e0-653b-43e4-a1c1-b59997b2762a).

About These Medications

  • Trazodone Hydrochloride (Desyrel) medication guide — Atypical Antidepressant
  • Ziprasidone Hydrochloride (Geodon) medication guide — Atypical Antipsychotic

Check other combinations with our interaction tool →

About this interaction data. These interactions were identified by automatically scanning FDA prescribing-label text for medications in Bridgeway's library. This is not a complete list and is not a substitute for review by your prescriber or pharmacist, who use comprehensive clinical databases. Always share your full medication list with your care team. How we source this data →

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Bridgeway's Utah prescribers coordinate medication management with therapy — so interactions like this one are reviewed by people who see your whole picture.

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Not medical advice. This page summarizes publicly available FDA drug labeling alongside general guidance from Bridgeway Integrated Healthcare Services. It is for educational purposes only and is not a substitute for advice from your prescriber or pharmacist. Never start, stop, or change a medication without talking to your healthcare provider. In an emergency, call 911.