Quetiapine Fumarate and Ziprasidone Hydrochloride: Interaction Overview

Quetiapine Fumarate (Seroquel) + Ziprasidone Hydrochloride (Geodon)

Severity: Minor

FDA label text mentions this combination without strong caution language. It is still worth confirming with your prescriber or pharmacist.

Basis: Warnings section of the Quetiapine Fumarate FDA label.

What the FDA Label Says

The use of quetiapine should be avoided in combination with other drugs that are known to prolong QTc including Class 1A antiarrythmics (e.g., quinidine, procainamide) or Class III antiarrythmics (e.g., amiodarone, sotalol), antipsychotic medications (e.g., ziprasidone, chlorpromazine, thioridazine), antibiotics (e.g., gatifloxacin, moxifloxacin), or any other class of medications known to prolong the QTc interval (e.g., pentamidine, levomethadyl acetate, methadone).

Excerpt from the FDA prescribing label for Quetiapine Fumarate (SPL set ID 02b19885-2987-4c46-8d2a-5e59656f72e8).

About These Medications

  • Quetiapine Fumarate (Seroquel) medication guide — Atypical Antipsychotic
  • Ziprasidone Hydrochloride (Geodon) medication guide — Atypical Antipsychotic

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About this interaction data. These interactions were identified by automatically scanning FDA prescribing-label text for medications in Bridgeway's library. This is not a complete list and is not a substitute for review by your prescriber or pharmacist, who use comprehensive clinical databases. Always share your full medication list with your care team. How we source this data →

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Not medical advice. This page summarizes publicly available FDA drug labeling alongside general guidance from Bridgeway Integrated Healthcare Services. It is for educational purposes only and is not a substitute for advice from your prescriber or pharmacist. Never start, stop, or change a medication without talking to your healthcare provider. In an emergency, call 911.