Fluoxetine Hydrochloride and Ziprasidone Hydrochloride: Interaction Overview

Fluoxetine Hydrochloride (Prozac) + Ziprasidone Hydrochloride (Geodon)

Severity: Minor

FDA label text mentions this combination without strong caution language. It is still worth confirming with your prescriber or pharmacist.

Basis: Drug interactions section of the Fluoxetine Hydrochloride FDA label.

What the FDA Label Says

These include: specific antipsychotics (e.g., ziprasidone, iloperidone, chlorpromazine, mesoridazine, droperidol); specific antibiotics (e.g., erythromycin, gatifloxacin, moxifloxacin, sparfloxacin); Class 1A antiarrhythmic medications (e.g., quinidine, procainamide); Class III antiarrhythmics (e.g., amiodarone, sotalol); and others (e.g., pentamidine, levomethadyl acetate, methadone, halofantrine, mefloquine, dolasetron mesylate, probucol or tacrolimus).

Excerpt from the FDA prescribing label for Fluoxetine Hydrochloride (SPL set ID 02283de9-6087-45f7-a9ce-3b082ce860de).

About These Medications

  • Fluoxetine Hydrochloride (Prozac) medication guide — SSRI
  • Ziprasidone Hydrochloride (Geodon) medication guide — Atypical Antipsychotic

Check other combinations with our interaction tool →

About this interaction data. These interactions were identified by automatically scanning FDA prescribing-label text for medications in Bridgeway's library. This is not a complete list and is not a substitute for review by your prescriber or pharmacist, who use comprehensive clinical databases. Always share your full medication list with your care team. How we source this data →

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Not medical advice. This page summarizes publicly available FDA drug labeling alongside general guidance from Bridgeway Integrated Healthcare Services. It is for educational purposes only and is not a substitute for advice from your prescriber or pharmacist. Never start, stop, or change a medication without talking to your healthcare provider. In an emergency, call 911.