Fluoxetine Hydrochloride and Lithium Carbonate: Interaction Overview

Fluoxetine Hydrochloride (Prozac) + Lithium Carbonate (Lithobid)

Severity: Moderate

FDA label language suggests this combination may require monitoring, dose adjustment, or added caution. Make sure every prescriber involved in your care knows you take both.

Basis: Warnings section — monitoring/caution language of the Fluoxetine Hydrochloride FDA label.

What the FDA Label Says

Suicidal thoughts and Behaviors in Children, Adolescents, and Young Adults: Monitor for clinical worsening and suicidal thinking and behavior ( 5.1 ) Serotonin Syndrome: Serotonin syndrome has been reported with SSRIs and SNRIs, including fluoxetine , both when taken alone, but especially when co-administered with other serotonergic agents (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, and St.

Excerpt from the FDA prescribing label for Fluoxetine Hydrochloride (SPL set ID 02283de9-6087-45f7-a9ce-3b082ce860de).

About These Medications

  • Fluoxetine Hydrochloride (Prozac) medication guide — SSRI
  • Lithium Carbonate (Lithobid) medication guide — Mood Stabilizer

Check other combinations with our interaction tool →

About this interaction data. These interactions were identified by automatically scanning FDA prescribing-label text for medications in Bridgeway's library. This is not a complete list and is not a substitute for review by your prescriber or pharmacist, who use comprehensive clinical databases. Always share your full medication list with your care team. How we source this data →

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Not medical advice. This page summarizes publicly available FDA drug labeling alongside general guidance from Bridgeway Integrated Healthcare Services. It is for educational purposes only and is not a substitute for advice from your prescriber or pharmacist. Never start, stop, or change a medication without talking to your healthcare provider. In an emergency, call 911.