Duloxetine Hydrochloride (Cymbalta) + Paroxetine Hydrochloride (Paxil)
FDA label text mentions this combination without strong caution language. It is still worth confirming with your prescriber or pharmacist.
Basis: Drug interactions section of the Duloxetine Hydrochloride FDA label.
Other drugs that inhibit CYP1A2 metabolism include cimetidine and quinolone antimicrobials such as ciprofloxacin and enoxacin [see Warnings and Precautions (5.12) ]. 7.2 Inhibitors of CYP2D6 Concomitant use of duloxetine (40 mg once daily) with paroxetine (20 mg once daily) increased the concentration of duloxetine AUC by about 60%, and greater degrees of inhibition are expected with higher doses of paroxetine.
Excerpt from the FDA prescribing label for Duloxetine Hydrochloride (SPL set ID 00628e5e-4c5b-2573-e063-6294a90a0e3b).
About this interaction data. These interactions were identified by automatically scanning FDA prescribing-label text for medications in Bridgeway's library. This is not a complete list and is not a substitute for review by your prescriber or pharmacist, who use comprehensive clinical databases. Always share your full medication list with your care team. How we source this data →
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Request an Appointment Call (801) 255-5131Not medical advice. This page summarizes publicly available FDA drug labeling alongside general guidance from Bridgeway Integrated Healthcare Services. It is for educational purposes only and is not a substitute for advice from your prescriber or pharmacist. Never start, stop, or change a medication without talking to your healthcare provider. In an emergency, call 911.