Duloxetine Hydrochloride and Lithium Carbonate: Interaction Overview

Duloxetine Hydrochloride (Cymbalta) + Lithium Carbonate (Lithobid)

Severity: Minor

FDA label text mentions this combination without strong caution language. It is still worth confirming with your prescriber or pharmacist.

Basis: Drug interactions section of the Duloxetine Hydrochloride FDA label.

What the FDA Label Says

Inhibition of the metabolism of CYP2C19 substrates is therefore not anticipated, although clinical studies have not been performed. 7.13 Monoamine Oxidase Inhibitors (MAOIs) [See Dosage and Administration (2.9 , 2.10) , Contraindications (4) , and Warnings and Precautions (5.4) ]. 7.14 Other Serotonergic Drugs The concomitant use of serotonergic drugs (including other SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, and St.

Excerpt from the FDA prescribing label for Duloxetine Hydrochloride (SPL set ID 00628e5e-4c5b-2573-e063-6294a90a0e3b).

About These Medications

  • Duloxetine Hydrochloride (Cymbalta) medication guide — SNRI
  • Lithium Carbonate (Lithobid) medication guide — Mood Stabilizer

Check other combinations with our interaction tool →

About this interaction data. These interactions were identified by automatically scanning FDA prescribing-label text for medications in Bridgeway's library. This is not a complete list and is not a substitute for review by your prescriber or pharmacist, who use comprehensive clinical databases. Always share your full medication list with your care team. How we source this data →

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Not medical advice. This page summarizes publicly available FDA drug labeling alongside general guidance from Bridgeway Integrated Healthcare Services. It is for educational purposes only and is not a substitute for advice from your prescriber or pharmacist. Never start, stop, or change a medication without talking to your healthcare provider. In an emergency, call 911.