Divalproex Sodium (Depakote) + Quetiapine Fumarate (Seroquel)
FDA label text mentions this combination without strong caution language. It is still worth confirming with your prescriber or pharmacist.
Basis: Warnings section of the Quetiapine Fumarate FDA label.
In the mania adjunct studies, where quetiapine was added to lithium or divalproex, 12% (24/196) of quetiapine treated patients compared to 7% (15/203) of placebo-treated patients had elevated TSH levels.
Excerpt from the FDA prescribing label for Quetiapine Fumarate (SPL set ID 02b19885-2987-4c46-8d2a-5e59656f72e8).
About this interaction data. These interactions were identified by automatically scanning FDA prescribing-label text for medications in Bridgeway's library. This is not a complete list and is not a substitute for review by your prescriber or pharmacist, who use comprehensive clinical databases. Always share your full medication list with your care team. How we source this data →
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Request an Appointment Call (801) 255-5131Not medical advice. This page summarizes publicly available FDA drug labeling alongside general guidance from Bridgeway Integrated Healthcare Services. It is for educational purposes only and is not a substitute for advice from your prescriber or pharmacist. Never start, stop, or change a medication without talking to your healthcare provider. In an emergency, call 911.