Clomipramine Hydrochloride (Anafranil) + Paroxetine Hydrochloride (Paxil)
FDA label text mentions this combination without strong caution language. It is still worth confirming with your prescriber or pharmacist.
Basis: Drug interactions section of the Clomipramine Hydrochloride FDA label.
While all the selective serotonin reuptake inhibitors (SSRIs), e.g., fluoxetine, sertraline, paroxetine, and fluvoxamine, inhibit P450 2D6, they may vary in the extent of inhibition.
Excerpt from the FDA prescribing label for Clomipramine Hydrochloride (SPL set ID 0bbee292-0fba-4606-9c8e-4723742682c0).
About this interaction data. These interactions were identified by automatically scanning FDA prescribing-label text for medications in Bridgeway's library. This is not a complete list and is not a substitute for review by your prescriber or pharmacist, who use comprehensive clinical databases. Always share your full medication list with your care team. How we source this data →
Bridgeway's Utah prescribers coordinate medication management with therapy — so interactions like this one are reviewed by people who see your whole picture.
Request an Appointment Call (801) 255-5131Not medical advice. This page summarizes publicly available FDA drug labeling alongside general guidance from Bridgeway Integrated Healthcare Services. It is for educational purposes only and is not a substitute for advice from your prescriber or pharmacist. Never start, stop, or change a medication without talking to your healthcare provider. In an emergency, call 911.