Buspirone Hydrochloride and Trazodone Hydrochloride: Interaction Overview

Buspirone Hydrochloride (Buspar) + Trazodone Hydrochloride (Desyrel)

Severity: Minor

FDA label text mentions this combination without strong caution language. It is still worth confirming with your prescriber or pharmacist.

Basis: Drug interactions section of the Trazodone Hydrochloride FDA label.

What the FDA Label Says

Examples triptans, antidepressants (tricyclic and serotonin uptake inhibitors), fentanyl, lithium, tramadol, tryptophan, buspirone, and St.

Excerpt from the FDA prescribing label for Trazodone Hydrochloride (SPL set ID 007f38e0-653b-43e4-a1c1-b59997b2762a).

About These Medications

  • Buspirone Hydrochloride (Buspar) medication guide — Anxiolytic
  • Trazodone Hydrochloride (Desyrel) medication guide — Atypical Antidepressant

Check other combinations with our interaction tool →

About this interaction data. These interactions were identified by automatically scanning FDA prescribing-label text for medications in Bridgeway's library. This is not a complete list and is not a substitute for review by your prescriber or pharmacist, who use comprehensive clinical databases. Always share your full medication list with your care team. How we source this data →

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Bridgeway's Utah prescribers coordinate medication management with therapy — so interactions like this one are reviewed by people who see your whole picture.

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Not medical advice. This page summarizes publicly available FDA drug labeling alongside general guidance from Bridgeway Integrated Healthcare Services. It is for educational purposes only and is not a substitute for advice from your prescriber or pharmacist. Never start, stop, or change a medication without talking to your healthcare provider. In an emergency, call 911.