Buspirone Hydrochloride and Fluvoxamine Maleate: Interaction Overview

Buspirone Hydrochloride (Buspar) + Fluvoxamine Maleate (Luvox)

Severity: Moderate

FDA label language suggests this combination may require monitoring, dose adjustment, or added caution. Make sure every prescriber involved in your care knows you take both.

Basis: Warnings section — monitoring/caution language of the Fluvoxamine Maleate FDA label.

What the FDA Label Says

It should be noted that fluvoxamine maleate extended-release capsules are not approved for use in treating bipolar depression. 5.2 Serotonin Syndrome The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including fluvoxamine maleate extended-release capsules, alone but particularly with concomitant use of serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, meperidine, methadone, lithium, tramadol, tryptophan, buspir

Excerpt from the FDA prescribing label for Fluvoxamine Maleate (SPL set ID 0a6836ab-bd0e-410b-82af-07720e386532).

About These Medications

  • Buspirone Hydrochloride (Buspar) medication guide — Anxiolytic
  • Fluvoxamine Maleate (Luvox) medication guide — SSRI

Check other combinations with our interaction tool →

About this interaction data. These interactions were identified by automatically scanning FDA prescribing-label text for medications in Bridgeway's library. This is not a complete list and is not a substitute for review by your prescriber or pharmacist, who use comprehensive clinical databases. Always share your full medication list with your care team. How we source this data →

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Not medical advice. This page summarizes publicly available FDA drug labeling alongside general guidance from Bridgeway Integrated Healthcare Services. It is for educational purposes only and is not a substitute for advice from your prescriber or pharmacist. Never start, stop, or change a medication without talking to your healthcare provider. In an emergency, call 911.