Aripiprazole and Fluoxetine Hydrochloride: Interaction Overview

Aripiprazole (Abilify) + Fluoxetine Hydrochloride (Prozac)

Severity: Moderate

FDA label language suggests this combination may require monitoring, dose adjustment, or added caution. Make sure every prescriber involved in your care knows you take both.

Basis: Drug interactions section — monitoring/caution language of the Aripiprazole FDA label.

What the FDA Label Says

7 DRUG INTERACTIONS Dosage adjustment due to drug interactions (7.1): Factors Dosage Adjustments for Aripiprazole Known CYP2D6 Poor Metabolizers Administer half of usual dose Known CYP2D6 Poor Metabolizers and strong CYP3A4 inhibitors Administer a quarter of usual dose Strong CYP2D6 or CYP3A4 inhibitors Administer half of usual dose Strong CYP2D6 and CYP3A4 inhibitors Administer a quarter of usual dose Strong CYP3A4 inducers Double usual dose over 1 to 2 weeks 7.1 Drugs Having Clinically Importa

Excerpt from the FDA prescribing label for Aripiprazole (SPL set ID 02a4af27-c83c-4166-950c-7a1cb12d198d).

About These Medications

  • Aripiprazole (Abilify) medication guide — Atypical Antipsychotic
  • Fluoxetine Hydrochloride (Prozac) medication guide — SSRI

Check other combinations with our interaction tool →

About this interaction data. These interactions were identified by automatically scanning FDA prescribing-label text for medications in Bridgeway's library. This is not a complete list and is not a substitute for review by your prescriber or pharmacist, who use comprehensive clinical databases. Always share your full medication list with your care team. How we source this data →

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Not medical advice. This page summarizes publicly available FDA drug labeling alongside general guidance from Bridgeway Integrated Healthcare Services. It is for educational purposes only and is not a substitute for advice from your prescriber or pharmacist. Never start, stop, or change a medication without talking to your healthcare provider. In an emergency, call 911.